Scrum is an effective approach for Agile Development. Opportunity Engineering (OE) is a business approach that allows to leverage uncertain business opportunities. We will present an effective framework that uses existing Development Agility and OE to enable real Business Agility. This framework uses Scrum to discover the right product to build by assessing business value under conditions of high-uncertainty (where real profits are). These concepts being already used by successful Internet companies, this presentation shows a ready-to-use framework applicable to any industry.